AB0114 INVESTIGATION OF THE EFFECTS OF EXERCISE ON MIRNA EXPRESSIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Background: The goal of treatment for patients with RA is achieve to remission, or at least a state low disease activity. Exercise recommended in addition drug therapy. It has been found be effective greatly improving functionality and reducing cardiovascular risk without exacerbating Therefore, it that all should encouraged include aerobic resistant exercise training as part their routine (1). miRNAs(miRNA) are known protect the pathophysiological process specific RA. miRNA-146a one miRNAs extensively studied RA, its expression was higher synovial fluid tissue compared healthy individuals (2). Many studies have miRNA-146a, along miRNA-16 miRNA155 may related pathology. also high levels correlate active inactive disease. increased level miRNA-155 causes problem modulation arthritis miRNA-145 peripheral blood mononuclear cells synovium supporting osteoclastogenesis (3,4,5). Objectives: aimed investigate effect on microRNA expressions rheumatoid (RA). Methods: 30 controls aged 18-60 years who met 2010 ACR / EULAR criteria were included study. A program consisting strengthening stretching exercises 2 days week applied study group 8 weeks. One day week, minutes mild moderate walking requested. Of cases beginning end treatment; 5-10 cc samples taken into EDTA tube. Then Numeric Rating Scale (NRS) used pain, 28-joint Disease Activity Score (DAS28) calculate activity, Health Assessment Questionnaire (HAQ) assess general health Short Form-36 (SF-36) evaluate quality life. only 1 tube control group. In taken, gene miRNA-155, miRNA-16, determined by real-time PZR method. Results: There significant difference DAS28, SF-36, NRS, HAQ scales before after (p 0.05). MiRNA-146a does not differ significantly (p> However, these two groups No observed pretreatment, posttreatment, Conclusion: therapy good life can affect vii some involved pathogenesis. more comprehensive needed. References: [1]Cooney JK, Law RJ, Matschke V, Lemmey AB, Moore JP, Ahmad Y, et al. Benefits arthritis. Journal Aging Research. 2011. p. 14. [2]Abou-Zeid A, Saad M, Soliman E. MicroRNA 146a arthritis: Association tumor necrosis factor-alpha Genet Test Mol Biomarkers. 2011;15(11):807–12. [3]Murata K, Yoshitomi H, Tanida S, Ishikawa Nishitani Ito Plasma microRNAs potential biomarkers osteoarthritis. Arthritis Res Ther. 2010;12(3):86. [4]Pauley KM, Satoh Chan AL, Bubb MR, Reeves WH, EKL. Upregulated miR-146a from patients. 2008;10(4):101. [5]Evangelatos G, Fragoulis GE, Koulouri Lambrou GI. Micrornas From pathogenesis clinical impact. Autoimmun Rev. 2019;18(11):102391. Disclosure Interests: None declared